Journal: Journal of Radiation Research
Article Title: Release of HMGB1 from human-derived cancer and normal cells by internal targeted radiotherapy with 131 I- meta -iodobenzylguanidine
doi: 10.1093/jrr/rraf034
Figure Lengend Snippet: The extracellular HMGB1 in the cultured medium of H441 (a) and HaCaT (b) at 1 day after X-ray irradiation, and SH-SY5Y (c) and HaCaT (d) at 1 day after 131 I- m -iodobenzylguanidine ( 131 I-MIBG) administration. HMGB1 release was significantly increased in H441 irradiated with 2-Gy and 10-Gy X-ray irradiation, but HaCaT was unchanged for both 2-Gy and 10-Gy. HMGB1 release was significantly increased after administering 1.85 MBq and 3.7 MBq of 131 I-MIBG, but was unchanged after all radioactivity. † P < 0.01 and * P < 0.05 versus the controls.
Article Snippet: The human-derived lung adenocarcinoma cell line H441 (American Type Culture Collection, Manassas, VA, USA) and the human-derived neuroblastoma cell line SH-SY5Y were used as cancer cells in this study along with the human keratinocyte cell line (HaCaT) as normal cells.
Techniques: Cell Culture, Irradiation, Radioactivity